Bilateral ophthalmic artery occlusions due to probable varicella-zoster virus vasculopathy.

with break points in introns 11 and 13 resulting in loss of exons 12 and 13 (Figure 2A and B). Further examination of the region showed a 34-bp repeat (differing by only 1 bp) flanking the break points, suggesting homologous recombination as the mechanism for generating this deletion. The predicted result of this deletion would be that exon 11 splices directly to exon 14 and remains in frame, resulting in a protein of 685 amino acids, compared with the wild-type protein of 829 amino acids (Figure 2E). This was confirmed using complementary DNA from patient and control lymphocytes and sequencing the products (Figure 2C and D).